Naturally occurring mutations in the reverse transcriptase region of hepatitis B virus polymerase from treatment-naïve Korean patients infected with genotype C2

Table 5 Frequency and patterns of 3 types of NAr Mutations related to hepatocellular carcinoma

Mutations	No. of patients		Nucleotide sequences	Codons in RT genes (patients)	Codons in HBsAg genes (patients)	P value
	CH	HCC
rtL80I	0	5	GGCTAT→GGATAT	CTA(L)→ATA(I) (5)	TAT(Y)→TAT(Y) (5)	0.036
rtN139K/T/H (sT131N/P)	0	8	GGAACC→GGAAAC	AAC(N)→AAA(K) (4)	ACC(T)→AAC(N) (4)
			→GGCACC	→CAC(H) (3)	→ACC(T) (3)	0.008
			→GGACCC	→ACC(T) (1)	→CCC(P) (1)
rtM204I/V (sW196L/S/W)	0	9	ATATGG→ATATTG	ATG(M)→ATT(I) (7)	TGG(W)→TTG(L) (7)
			→ATATCG	→ATC(I) (1)	→TCG(S) (1)	0.004
			→ATGTGG	→GTG(V) (1)	→TGG(W) (1)

The point mutation bases of the three truncations are shown in bold and italic. H: Histidine; I: Isoleucine; K: Lysine; L: Leucine; M: Methionine; N: Asparagine; P: Proline; S: Serine; T: Threonine; V: Valine; W: Tryptophan; Y: Tyrosine; CH: Chronic hepatitis; HCC: Hepatocellular carcinoma.