Naturally occurring mutations in the reverse transcriptase region of hepatitis B virus polymerase from treatment-naïve Korean patients infected with genotype C2

Table 4 Mutation site distributions and mutation rate in different sections of hepatitis B virus RT and overlapped hepatitis B surface antigen regions

	Region (amino acid)	No. of mutation site	Mutation frequency	P value
Reverse transcriptase	Domain (22)	9 (40.9)	1.07%	0.008
	A-B interdomain (6)	6 (100)	7.50%	-
	Non A-B interdomain (14)	10 (71.4)	3.16%	NS
	Total (42)	25 (59.5)	2.68%	-
HBsAg	A-determinant (3)	2 (66.6)	3.81%
	Non A-determinant (37)	8 (21.6)	0.55%	< 0.001
	Total (40)	10 (28.5)	0.80%	-

Statistics were calculated between Domain/Non A-B interdomain and A-B interdomain in reverse transcriptase region. In category 2, the statistical significant showed between A-determinant and Non-A-determinant in HBsAg region.