Naturally occurring mutations in the reverse transcriptase region of hepatitis B virus polymerase from treatment-naïve Korean patients infected with genotype C2

Table 2 Correlation between the frequency of potential nucleos(t)ide analog resistance mutation and clinical features

No. of mutations	CH/HCC	HBeAg (positive/negative)	ALT (IU/L)	AST (IU/L)	HBV DNA	HBsAg
0	27/25	29/23	108.51 ± 105.8	122.92 ± 106.8	6.50 ± 6.5	3.97 ± 3.8
1	18/16	21/13	101.61 ± 108.7	71.42 ± 126.1a	6.91 ± 6.4	3.95 ± 3.8
2	9/19	15/13	81.10 ± 113.8	113.75 ± 113.0	6.65 ± 6.1	3.65 ± 3.9a
3	4/7	3/8	211.45 ± 97.3	205.18 ± 104.8a	6.84 ± 6.5	3.84 ± 3.8
4	1/4	2/3	56.60 ± 108.8	72.00 ± 114.8	5.85 ± 6.5	3.68 ± 3.8
5	0/1	1/0	24.23	39.05	7.49	2.83
≥ 1 (n = 79)	32/47	42/37	105.81 ± 216.19	106.86 ± 131.51	5.11 ± 1.55	3.37 ± 0.77
Total (n = 131)	59/72	71/60	107.21 ± 191.16	113.2 ± 141.06	4.98 ± 1.51	3.43 ± 0.73

The significant values were shown in boldface and marked with asterisk (^aP < 0.05). HbsAg: Hepatitis B virus surface antigen; HCC: Hepatocellular carcinoma.