Naturally occurring mutations in the reverse transcriptase region of hepatitis B virus polymerase from treatment-naïve Korean patients infected with genotype C2

Table 1 Comparison of clinical data between chronic hepatitis and hepatocellular carcinoma patients

Clinical factors	CH (n = 59)	HCC (n = 72)	Total (n = 131)	P value
Age, yr, mean ± SD	38.9 ± 11.1	52.3 ± 9.7	45.7 ± 12.3	< 0.001
Gender, male	47.40%	79.10%	64.80%	< 0.001
HBeAg negative	35.50%	54.10%	45.80%	0.04%
ALT (IU/L), mean ± SD	94.5 ± 105.6	74.2 ± 85.1	106.8 ± 191.2	NS
AST (IU/L), mean ± SD	70.4 ± 92.0	127.1 ± 139.8	113.2 ± 141.0	< 0.001
HBV DNA	6.5 ± 2.0	5.3 ± 1.1	6.53 ± 1.7	< 0.001
HBsAg	3.7 ± 0.6	3.3 ± 0.7	3.43 ± 0.6	< 0.001

HbsAg: Hepatitis B virus surface antigen.