Solid lipid nanoparticles delivering anti-inflammatory drugs to treat inflammatory bowel disease: Effects in an in vivo model

doi:10.3748/wjg.v23.i23.4200

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 21, 2017; 23(23): 4200-4210
Published online Jun 21, 2017. doi: 10.3748/wjg.v23.i23.4200

Table 2 Concentration of main components of water dispersion of cholesteryl butyrate and dexamethasone cholesteryl butyrate-solid lipid nanoparticles formulations after 4 washing steps (HPLC method determination)

Molar composition of final dispersion after washing	Cb, mmol/L	DxCb-SLN, mmol/L
Dexamethasone 21-acetate	-	1.1
Cholesteryl butyrate	36.0	38.5
Phosphatidylcholine	48.4	49.2
Sodium glycocholate	12.5	11.2

Cb: Cholesteryl butyrate; DxCb-SLN: Dexamethasone cholesteryl butyrate-solid lipid nanoparticles.

Citation: Dianzani C, Foglietta F, Ferrara B, Rosa AC, Muntoni E, Gasco P, Della Pepa C, Canaparo R, Serpe L. Solid lipid nanoparticles delivering anti-inflammatory drugs to treat inflammatory bowel disease: Effects in an in vivo model. World J Gastroenterol 2017; 23(23): 4200-4210
URL: https://www.wjgnet.com/1007-9327/full/v23/i23/4200.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i23.4200