Drug-induced liver injury in inflammatory bowel disease: 1-year prospective observational study

doi:10.3748/wjg.v23.i22.4102

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 14, 2017; 23(22): 4102-4111
Published online Jun 14, 2017. doi: 10.3748/wjg.v23.i22.4102

Table 2 Prevalence of liver injury events among all aminotransferase measurements in 251 inflammatory bowel disease patients over 1 year n (%)

Liver injury event	All measurements	Abnormal
Liver injury event	n	Number of events
ALT increase Grade 1 (0-3 × ULN)	917	112 (12.21)
ALT increase > 2 × ULN (hepatocellular injury)	917	26 (2.84)
ALT increase Grade 2 (> 3 × ULN)	917	6 (0.65)
AST increase Grade 1 (0-3 × ULN)	917	55 (6.0)
AST increase Grade 2 (> 3 × ULN)	917	8 (0.87)
GGT increase Grade 1 (0-2.5 × ULN)	895	80 (8.94)
GGT increase Grade 2 (> 2.5 × ULN)	895	24 (2.68)
ALP increase Grade 1 (0-2.5 × ULN)	897	34 (3.79)
ALP increase Grade 2 (> 2.5 × ULN)	897	0 (0)
Cholestasis (parallel ALP and GGT elevation)	895	11 (1.23)
Total bilirubin > 2 × ULN	370	1 (0.27)

ULN: Upper limit of normal; ALT: Alanine aminotransferase; AST: Aspratate aminotransferase; GGT: Gamma-glutamyl transpeptidase; ALP: Alkaline phosphatase.

Citation: Koller T, Galambosova M, Filakovska S, Kubincova M, Hlavaty T, Toth J, Krajcovicova A, Payer J. Drug-induced liver injury in inflammatory bowel disease: 1-year prospective observational study. World J Gastroenterol 2017; 23(22): 4102-4111
URL: https://www.wjgnet.com/1007-9327/full/v23/i22/4102.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i22.4102