Association of keratin 8/18 variants with non-alcoholic fatty liver disease and insulin resistance in Chinese patients: A case-control study

Table 2 Distribution of keratin variants in non-alcoholic fatty liver disease patients and controls

Keratin gene	Variant		NAFLD
	Nucleotide	Amino acid	Control (n = 173)	Total (n = 200)	NAFLD with IR (n = 79)	NAFLD without IR (n = 121)
K8	1022G→A	R341H	1	2	2	0
	904C→T	R302C	0	1	1	0
	1381G→A	V461M	0	1	0	1
	IVS5-9A→G (new)		0	1	1	0
	IVS3-26 C→T		0	1	1	0
K18	IVS6+19G→A (new)		0	1	1	0
	IVS6+17C→T		0	1	0	1
	IVS3-15C→G		0	11	11	0
	1590C→G	N193S (new)	0	11	11	0
	1448A→G	T195T (new)	0	1	0	1
Total (%)			1 (0.58)	10 (5.00)	7 (8.86)	3 (2.48)

¹One patient carries two K8/K18 variants (K18 N193S+K8 IVS3-15C→G). The table displays the number of patients with NAFLD and controls harboring the listed keratin variants. IR: Insulin resistance; NAFLD: Non-alcoholic fatty liver disease.