Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update

doi:10.3748/wjg.v23.i22.3978

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 14, 2017; 23(22): 3978-3998
Published online Jun 14, 2017. doi: 10.3748/wjg.v23.i22.3978

Table 4 Summary of global gene expression studies in gallbladder cancer

Biological sample used	Platform/studies key findings	Ref.
17 gallbladder tissue specimens (6 advanced GBC , 6 early GBC cancers and 5 normal control	Oligonucleotide Microarray platform	[97]
	Unregulated genes: 2270
	Downregulated genes: 2412
5-Normal biliary epithelial scrapings, 11- surgically resected biliary carcinomas, 9-biliary cancer cell lines	Oligonucleotide Microarray platform	[98]
	Unregulated genes : 282 genes
	Downregulated genes: 513
37 biliary tract carcinomas	cDNA array platform	[99]
(15 bile duct, 11 gallbladder, 11 of ampulla of Vater)	118 genes were identified with a prognostic value	[99]
12 advanced gallbladder carcinoma tissue 3 samples of normal control gallbladder epithelium	Oligonucleotide Array platform	[100]
	Upregulated: (TOPO II-alpha, cyclin B2, CDC28, ubiquitin-conjugating enzyme E2C), and one metabolism-related: (gamma-glutamyl hydrolase)	[101]
34 biliary tract cancers including	Oligonucleotide Array platform	[101]
13 intrahepatic (IHC), 12extrahepatic (EHC), 9 (GBC)	1281 genes with deregulated expression pattern

Citation: Sharma A, Sharma KL, Gupta A, Yadav A, Kumar A. Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update. World J Gastroenterol 2017; 23(22): 3978-3998
URL: https://www.wjgnet.com/1007-9327/full/v23/i22/3978.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i22.3978