Corticotropin-releasing factor stimulates colonic motility via muscarinic receptors in the rat

Figure 3 Effects of atropine and tetrodotoxin on corticotropin-releasing factor-induced colonic motility in the proximal colon. Atropine (10^-5 mol/L) reduced MI from 112.5% ± 22.0% to 34.3% ± 17.8% (P < 0.05). Administration of tetrodotoxin (10^-6 mol/L) reduced MI from 112.5% ± 22.0% to 21.1% ± 9.8% (P < 0.01). ^aP < 0.05; ^bP < 0.01. CRF: Corticotropin-releasing factor; MI: Motility index.