Corticotropin-releasing factor stimulates colonic motility via muscarinic receptors in the rat

Figure 2 Concentration-response curves for corticotropin-releasing factor-induced contractility in isolated vascularly perfused rat colons. CRF increased both proximal and distal colonic motility. Concentration-motility was observed only in the proximal colon. Data are expressed as percent change of MI over basal. Each data point represents the mean of 6 experiments. ^aP < 0.05; ^bP < 0.01. CRF: Corticotropin-releasing factor; MI: Motility index; R: Correlation coefficient.