Validation of a serum microRNA panel as biomarkers for early diagnosis of hepatocellular carcinoma post-hepatitis C infection in Egyptian patients

Table 3 Diagnostic ability for studied miRNA to categorize hepatocellular carcinoma among hepatitis C virus-infected fibrotic patients and controls

Serum miRNA	AUC value	Sensitivity	Specificity	PPV	NPV	Accuracy
miR-214-5P
HCC against ctrl	0.721	61.0%	89.0%	81.0%	75.0%	77.0%
HCC against HCV	0.842	92.9%	75.5%	51.0%	97.5%	80.0%
miR-494
HCC against ctrl	0.813	77.0%	76%	69.0%	82.0%	76.0%
HCC against HCV	0.631	77.0%	56%	32.0%	90.0%	60.0%
miR-138p
HCC against ctrl	0.842	96.4%	78.4%	77.1%	96.0%	86.0%
HCC against HCV	0.642	68.2%	58.2%	34.0%	90.0%	62.0%
miR-125b
HCC against ctrl	0.702	66.7%	75.7%	66.7%	75.7%	72.0%
HCC against HCV	0.769	92.6%	55.4%	35.7%	96.6%	63.3%
miR-1269
HCC against ctrl	0.862	96.4%	78.4%	77.1%	96.7%	86.2%
HCC against HCV	0.691	78.6%	59.8%	34.9%	91.0%	63.8%
miR-145
HCC against ctrl	0.892	100.0%	89.2%	87.1%	100.0%	93.8%
HCC against HCV	0.624	81.5%	51.5%	30.6%	91.4%	57.7%
miR-375
HCC against ctrl	0.741	96.4%	59.5%	63.4%	95.7%	75.4%
HCC against HCV	0.811	96.4%	69.3%	46.6%	98.6%	75.2%

AUC: Area under curve, PPV: Positive predictive value, NPV: Negative predictive value.