Prevalence of IFNL3 rs4803217 single nucleotide polymorphism and clinical course of chronic hepatitis C

doi:10.3748/wjg.v23.i21.3815

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 7, 2017; 23(21): 3815-3824
Published online Jun 7, 2017. doi: 10.3748/wjg.v23.i21.3815

Table 4 Association of IFNL3 (IL28B) rs4803217 and rs8099917 combined genotypes with response to pegylated interferon alpha and ribavirin treatment

Genotypes/combined genotypes	SVR (n = 54), n	Non-response (n = 126), n	OR (95%CI)	P value
rs4803217CC/rs8099917TT	22	13	0.697 (0.276-1.759)	0.442
rs4803217CC/rs8099917TG	12	1	4.941 (0.586-41.699)	0.156
rs4803217CC¹	34	14	Ref.	-
rs4803217CA/rs8099917TT	5	9	2.813 (0.832-9.504)	0.136
rs4803217CA/rs8099917TG	9	71	0.641 (0.267-1.542)	0.388
rs4803217CA/rs8099917GG	2	1	10.125 (0.865-118.471)	0.083
rs4803217CA	16	81	Ref.	-
rs4803217AA/rs8099917TT	1	2	5.167 (0.355-75.138)	0.298
rs4803217AA/rs8099917TG	1	14	0.738 (0.070-7.736)	1.000
rs4803217AA/rs8099917GG	1	15	0.689 (0.066-7.192)	1.000
rs4803217AA	3	31	Ref.	-

¹Combination of rs4803217CC and rs8099917GG genotypes was not observed. SNP: Single nucleotide polymorphism; SVR: Sustained virological response.

Citation: Świątek-Kościelna B, Kałużna E, Strauss E, Nowak J, Bereszyńska I, Gowin E, Wysocki J, Rembowska J, Barcińska D, Mozer-Lisewska I, Januszkiewicz-Lewandowska D. Prevalence of IFNL3 rs4803217 single nucleotide polymorphism and clinical course of chronic hepatitis C. World J Gastroenterol 2017; 23(21): 3815-3824
URL: https://www.wjgnet.com/1007-9327/full/v23/i21/3815.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i21.3815