Prevalence of IFNL3 rs4803217 single nucleotide polymorphism and clinical course of chronic hepatitis C

doi:10.3748/wjg.v23.i21.3815

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jun 7, 2017; 23(21): 3815-3824
Published online Jun 7, 2017. doi: 10.3748/wjg.v23.i21.3815

Table 2 Association between IFNL3 (IL28B) single nucleotide polymorphism and sustained virological response after pegylated interferon alpha and ribavirin treatment in chronic hepatitis C patients

SNP	Allele/genotype	Response (n = 54), n (%)	Non-response (n = 126), n (%)	Response vs non-response	OR_crude (95%CI)/OR_adjusted (95%CI)¹	P_crude/P_adjusted¹
rs4803217 (C/A)	C/A	85 (78.70)/23 (21.30)	109 (43.25)/143 (56.75)	C/A	4.848 (2.871-8.186)	< 0.0001^a
	CC	34 (62.96)	14 (11.11)	CC/CA + AA	13.6 (6.219-29.770)/8.357 (3.013-23.181)	< 0.0001^a/< 0.0001^a
	CA	17 (31.48)	81 (64.29)	CC + CA/AA	5.547 (1.617-19.035)/3.240 (0.849-12.367)	0.003^a/0.082
	AA	3 (55.56)	31 (24.60)	Dose of C allele	7.588 (3.858-14.922)/4.310 (1.956-9.500)	< 0.0001^a/0.0002^a
rs12979860 (C/T)	C/T	82 (75.93)/26 (24.07)	108 (42.86)/144 (57.14)	C/T	4.205 (2.533-6.980)	< 0.0001^a
	CC	32 (59.26)	14 (11.11)	CC/CT + TT	11.636 (5.351-25.306)/9.765 (3.407-27.990)	< 0.0001^a/< 0.0001^a
	CT	18 (33.33)	80 (63.49)	CC + CT/TT	4.255 (1.424-12.715)/4.413 (0.927-21.011)	0.006^a/0.059
	TT	4 (7.41)	32 (25.40)	Dose of C allele	6.072 (3.195-11.538)/5.574 (2.345-13.246)	< 0.0001^a/< 0.0001^a
rs8099917 (T/G)	T/G	80 (74.07)/28 (25.93)	149 (59.13)/103 (40.87)	T/G	1.975 (1.2-3.251)	0.007^a
	TT	29 (53.70)	39 (30.95)	TT/TG + GG	2.588 (1.344-4.981)/2.097 (0.844-5.210)	0.004^a/0.107
	TG	22 (40.74)	71 (56.35)	TT + TG/GG	2.473 (0.690-8.867)/2.397 (0.482-11.926)	0.153/0.280
	GG	3 (5.56)	16 (12.70)	Dose of T allele	2.190 (1.266-3.788)/1.869 (0.911-3.837)	0.0048^a/0.0845
rs12980275 (A/G)	A/G	85 (78.70)/23 (21.30)	120 (47.62)/132 (52.38)	A/G	4.065 (2.410-6.857)	< 0.0001^a
	AA	35 (64.81)	23 (18.25)	AA/AG + GG	8.249 (4.021-16.923)/5.225 (1.999-13.658)	< 0.0001^a/0.001^a
	AG	15 (27.78)	74 (58.73)	AA + AG/GG	3.737 (1.244-11.223)/4.075 (0.848-19.589)	0.013^a/0.076
	GG	4 (7.41)	29 (23.02)	Dose of A allele	4.705 (2.591-8.542)/3.596 (1.659-7.791)	< 0.0001^a/0.001^a

¹Adjusted for staging;

^aP < 0.05. SNP: Single nucleotide polymorphism.

Citation: Świątek-Kościelna B, Kałużna E, Strauss E, Nowak J, Bereszyńska I, Gowin E, Wysocki J, Rembowska J, Barcińska D, Mozer-Lisewska I, Januszkiewicz-Lewandowska D. Prevalence of IFNL3 rs4803217 single nucleotide polymorphism and clinical course of chronic hepatitis C. World J Gastroenterol 2017; 23(21): 3815-3824
URL: https://www.wjgnet.com/1007-9327/full/v23/i21/3815.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i21.3815