New endoscopes and add-on devices to improve colonoscopy performance

Table 3 New endoscopes and colonoscopy performance improvement

Ref.	Study design	Technology	Comparator	N	Indication	Age (yr), range	CIR (%)	PDR (%)	ADR (%)	APC	PMR (%)	AMR (%)
Gralnek et al[23], 2013	Single-center prospective,	FUSE	None	50	Mixed	18-70	100%	-	-	N/A	N/A	N/A
Gralnek et al[25], 2014	Multicenter, prospective, randomized, tandem	FUSE	SFV	101 vs 96	Mixed	18-70	98.0% vs 98.9%	-	134.0% vs 28.0%	10.64 vs 0.33	10%vs 43%	7% vs 41%
Papanikolaou et al[26], 2017	Multicenter, prospective randomized, tandem	FUSE	SFV+R	107 vs 108	Mixed	41-80	-	-	-	10.61 vs 0.50	13.0% vs 33.5%	10.9% vs 33.7%
Hassan et al[29], 2016	Multicenter, prospective, randomized parallel	FUSE	SFV	328vs 330	Screening after (+) FIT	50-69	92.1% vs 93.3%	-	43.6% vs 45.5%	0.81 vs 0.85	N/A	N/A
Song et al[24], 2016	Singe-center retrospective,	FUSE	None	262	Mixed	22-80	100%	54.20%	36.3%	0.66	N/A	N/A
Rath et al[31], 2015	Multicenter, prospective, parallel	FUSE	SFV	90	-	-	-	36% vs 24.0%	-	-	N/A	N/A
Manes et al[27], 2016 Abstract	Single-center prospective, parallel	FUSE	SFV	264 vs 265	Mixed	18-85	-	56.6% vs 44.3%	35.5% vs 29.9%	-	N/A	N/A
Roepstorff et al[28], 2016 Abstract	Single-center prospective, parallel	FUSE	SFV	109 vs 106	Screening	-	83.4% vs 93.4%	N/A	67.0% vs 59.6%	1.8 vs 1.4	N/A	N/A
Leong et al[30], 2016 Abstract	Single-center, prospective, randomized tandem	FUSE	SFV	25 vs 27	IBD	-	-	-	-	-	225.0% vs 71.4%	-
Uraoka et al[33], 2015	Multicenter, feasibility	EWAVC	None	47	Mixed	-	100%	-	-	0.64	N/A	N/A
Uraoka et al[34], 2013 Abstract	Multicenter, prospective, randomized parallel	EWAVC	SFV	316	Mixed	-	-	-	50.6% vs 45.6%	1.1 vs 1.0	N/A	N/A
Gluck et al[35], 2016	Single-center, prospective, tandem	Aer-O-Scope	SFV	56	Screening	27-72	98.2% vs 98.2%	-	21.4% vs 25.0%	-	12.5% for Aer-O-Scope	-

¹Refers to the first of the tandem examinations;

²Dysplasia miss-rate. N/A: Non-applicable; -: Data not provided; CIR: Cecal intubation rate; PDR: Polyp detection rate; ADR: Adenoma detection rate; APC: Adenoma per colonoscopy; PMR: Polyp miss rate; AMR: Adenoma miss rate; FUSE: Full-spectrum endoscopy platform; SFV: Standard forward view colonoscope; SFV + R: Standard forward view colonoscope + retroflexion in cecum; EWAC: Extra-wide-angle view colonoscope; IBD: Inflammatory bowel disease.