Endoscopic shielding technique, a new method in therapeutic endoscopy

Table 1 Outcomes of endoscopic shielding techniques with different experimental models

Ref.	Year	n	Species	Location of lesions	Substance	Primary endpoint	Efficacy
Maeng et al[4]	2014	12/2	Rabbit/pigs	Stomach	EGF-CS	Mucosal healing	90%-95%
Takao et al[5]	2015	9	Pigs	Stomach	PGA-FG	Prevent late complications	100%
Hiroyuki et al[6]	2016	20	Canine	Stomach	PGA-FG with suture	Prevent late complications	100%
Lorenzo-Zúñiga et al[7]	2016	4/16	Pigs/rats	Colon	PRP	Prevent late perforation and mucosal healing	100% and 2.4% (control) vs 80% (treated)
Lorenzo-Zúñiga et al[8]	2017	8/24	Pigs/rats	Colon	HAMPA	Prevent late perforation	100%

PGA: Polyglycolic acid sheets; FG: Fibrin glue; EGF-CS: Hydrogel epidermal growth factor with chitosan; PRP: Platelet rich plasma; HAMPA: Hydrogel based on the combination of hyaluronic acid, methylcellulose, poloxamer 407 and a non-absorbable antibiotic.