M2-like Kupffer cells in fibrotic liver may protect against acute insult

Figure 3 Kupffer cells in the fibrotic liver exhibit predominantly a M2-like activation. KCs were isolated from the livers of normal, acutely injured (D-GalN/LPS) and fibrotic mice, and M1 and M2 gene signatures were then determined by quantitative real-time PCR. Data are expressed as mean ± SEM. ^aP < 0.05 vs the control group, ^bP < 0.05 vs the D-GalN/LPS group, ^cP < 0.05 vs the control group, ^dP < 0.05 vs the fibrosis group. D-GalN: D-galactosamine; KCs: Kupffer cells; LPS: Lipopolysaccharide.