Cyclooxygenase 2 in liver dysfunction and carcinogenesis: Facts and perspectives

doi:10.3748/wjg.v23.i20.3572

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May 28, 2017 (publication date) through Sep 1, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 28, 2017; 23(20): 3572-3580
Published online May 28, 2017. doi: 10.3748/wjg.v23.i20.3572

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Figure 2 Mice carrying a COX-2 transgene in hepatocytes have elevated PGE₂ and are protected against hepatic insults. PGE₂ produced by hepatic COX-2 has specific effects in liver against inflammation, steatosis, fibrosis and apoptosis. At the systemic level protection against insulin resistance and adiposity is observed, whereas angiogenesis and thermogenesis are enhanced.

Citation: Martín-Sanz P, Casado M, Boscá L. Cyclooxygenase 2 in liver dysfunction and carcinogenesis: Facts and perspectives. World J Gastroenterol 2017; 23(20): 3572-3580
URL: https://www.wjgnet.com/1007-9327/full/v23/i20/3572.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i20.3572