Different techniques for harvesting grafts for living donor liver transplantation: A systematic review and meta-analysis

Table 4 Results of meta-analysis comparison of minimally invasive living donor hepatectomy and conventional living donor hepatectomy

Outcome of interest	Study (n)	MILDH (n)	CLDH (n)	WMD/OR (95%CI)	P value	Study heterogeneity			P value
						I2	df	I2, %
Graft weight (g)	5	123	119	-3.32 (-22.25,15.61)	0.73	6.56	4	39	0.16
Donor outcomes
Operative time (min)	13	476	1116	20.68 (-6.25,47.60)	0.13	147.62	12	92	< 0.01
Estimated blood loss (mL)	12	450	1092	-32.61 (-80.44,15.21)	0.18	61.26	11	82	< 0.01
Hospital cost (dollar)	2	36	36	0.56 (-0.62,1.74)	0.35	4.24	1	76	0.04
Length of hospital stay (d)	10	392	575	-1.25 (-2.35,-0.14)	0.03	99.31	9	91	< 0.01
Post complications	12	451	632	0.62 (0.44,0.89)	0.009	4.40	11	0	0.96
Analgesic use (h)	5	139	167	-7.97 (-14.06,-1.87)	0.01	7.50	4	47	0.11
Liver function
Post AST peak (IU/L)	7	334	471	6.41 (-3.79.16.60)	0.22	13.60	6	56	0.03
Post ALT peak (IU/L)	8	350	485	11.86 (-10.84,34.57)	0.31	15.39	7	55	0.03
Post TB peak (mg/dL)	7	324	461	-0.10 (-0.26,0.06)	0.21	2.10	6	0	0.91
Recipient outcomes
Liver function
Post AST peak (IU/L)	3	59	59	-28.73 (-86.76,29.31)	0.33	0.90	2	0	0.64
Post ALT peak (IU/L)	3	59	59	-29.98 (-87.65,27.7)	0.31	0.31	2	0	0.86
Post TB peak (mg/dL)	3	59	59	-0.96 (-2.57,0.65)	0.24	1.26	2	0	0.53
Surviving	3			0.96 (0.27,3.47)	0.95	0.11	2	0	0.95
Post complications	6	272	375	0.93 (0.66,1.31)	0.68	3.28	5	0	0.66

MILDH: Minimally invasive living donor hepatectomy; CLDH: Conventional living donor hepatectomy; WMD/OR: Weight mean difference/odds ratio; df: Degree of freedom; Post: Postoperative.