Urinary metabolic insights into host-gut microbial interactions in healthy and IBD children

Table 4 Overview of metabolites associated with anthropometric parameters

Metabolic pathways	Metabolites	Anthropometric parameters
		Fat mass %		BMI		BMI z-score		Body weight
		r	VIP	r	VIP	r	VIP	r	VIP
TCA cycle	L-2-hydroxyglutaric acid	0.41	1.57	0.22	1.23	0.29	1.36	0.14	1.07
	Oxoglutaric acid	0.48	1.66	0.29	1.32	0.35	1.41	0.13	0.91
	Succinic acid	0.39	1.50	0.17	1.12	0.24	1.24	0.10	0.98
Bacterial metabolism	3-hydroxyphenylacetic acid	0.44	1.49	0.27	1.20	0.29	1.22	0.23	1.07
	Hippuric acid	0.32	1.27	0.27	1.27	0.28	1.26	0.19	1.03
	Phenol	0.44	1.42	0.42	1.57	0.48	1.68	0.26	1.10
Bile acids	12_ketoLCA	0.34	1.13	0.41	1.53	0.40	1.40	0.39	1.48
	DCA	0.48	1.62	0.48	1.82	0.50	1.76	0.52	2.02
	GDCA	0.48	1.58	0.49	1.85	0.47	1.66	0.53	2.01
	GHDCA	0.38	1.28	0.49	1.81	0.42	1.47	0.45	1.69
	GLCA	0.19	0.87	0.32	1.28	0.30	1.17	0.43	1.69
	LCA	0.35	1.16	0.37	1.40	0.34	1.20	0.41	1.57
	NORDCA	0.37	1.25	0.45	1.65	0.44	1.54	0.57	2.13
	TUDCA	-0.12	0.81	-0.32	1.35	-0.31	1.27	-0.43	1.65
	UCA	-0.30	0.96	-0.38	1.39	-0.33	1.16	-0.35	1.42
	UDCA	-0.11	0.70	-0.42	1.60	-0.38	1.39	-0.44	1.65
Amino acid metabolism	Aminoadipic acid	0.36	1.41	0.22	1.20	0.25	1.23	0.17	1.06
	L-Asparagine	0.26	0.89	0.34	1.33	0.36	1.30	0.27	1.21
	L-Histidine	0.30	1.33	0.33	1.48	0.34	1.47	0.31	1.42
	L-Methionine	0.31	1.39	0.16	1.16	0.24	1.29	0.09	1.03
	L-Proline	0.30	1.35	0.15	1.13	0.23	1.27	0.10	1.06
	L-Tryptophan	0.32	1.39	0.29	1.41	0.34	1.50	0.22	1.21
	L-Tyrosine	0.27	1.29	0.23	1.26	0.26	1.32	0.15	1.07
	N-acetyltryptophan	0.32	1.42	0.28	1.41	0.33	1.50	0.22	1.23

12-KetoLCA: 12-ketolithocholic acid; DCA: Deoxycholic acid; GDCA: Glycodeoxycholic acid; GHDCA: Glycohyodeoxycholate; GLCA: Glycolithocholate; LCA: Lithocholic acid; NORDCA: 3α,12α-dihydroxynorcholanate/23-nordeoxycholic acid; TUDCA: Tauroursodeoxycholic acid; UCA: Ursocholic acid; UDCA: Ursodeoxycholic acid.