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©The Author(s) 2017.
World J Gastroenterol. May 28, 2017; 23(20): 3589-3606
Published online May 28, 2017. doi: 10.3748/wjg.v23.i20.3589
Published online May 28, 2017. doi: 10.3748/wjg.v23.i20.3589
Table 8 Long-term response rates and predictors of sustained seroprotection after hepatitis A virus vaccination in human immunodeficiency virus-positive patients
Ref. | Dates | Design/Country | No. of patient1 | HAV/dosing schedules (mo) | CD4, cells/mm3 | PVL, log10, copies/mL | ART (%) | Timing of assay2, yr/cut-off3, mIU/mL/Assay | Response rate (%): ITT/PP | Predictors of persistent response and comments4 |
Cheng et al[136] | 2010-2015 | Prospective, Taiwan | Primary responders: | HAVRIX 1440 U/ | 560/415 | 2.5/2.8 | 70/56 | 2, 3, 4, 5/20 | At 1.5 yr: | MSM only study; 3-doses over 2-dose, syphilis, lack of acute HCV |
2 doses, 110 | 2 doses (0, 6) | ELISA (ETIAB- HAVK PLUS) | 2 doses: 90.0/93.4 | |||||||
3 doses, 185 | 3 doses (0, 1, 6) | 3 doses: 87.0/94.7 | ||||||||
Non- | 470/315 | 2.9/3.3 | 59/63 | At 5 yr: | ||||||
responders: | 2 doses: 76.4/88.4 | |||||||||
2 doses, 16 | 3 doses: 78.9/94.2 | |||||||||
3 doses, 23 | ||||||||||
Kernéis et al[137] | 2006-2009 | Prospective, France | Primary responders: | HAVRIX 1440/ | 362 | 62%5 | NA | 7, 43/20 | At 3.7 yr: | PVL < 50 copies/mL at time of last vaccine dose and a short duration of HIV infection |
71 (52) | 2 doses (0, 6) | ELISA (ETIAB- | Overall: 61.9/84.6 | |||||||
3 doses (0, 1, 6) | HAVK PLUS) | |||||||||
Jablonowska et al[138] | 2004 | Prospective, Poland | Primary responders: | HAVRIX 1440 | 450 | NA | 37 | 1.5, 5/20 | At 1.5 yr: | Lack of co-infection with HCV |
66 | (0, 6) | CIA (Cobas, Roche) | 75.8/81.9 | |||||||
At 5 yr: | ||||||||||
56.1/75.5 | ||||||||||
Crum-Cianflone et al[135] | 1996-2003 | Retrospective, United States | 116 | Vaqta 50 or HAVRIX 1440 (0, 6-18) | Median, 467 | 50%5 | 62 | 3, 6-10/10 | At 3 yr: | Lower PVL; PVL < 400 copies/mL |
90 | ||||||||||
At 6-10 yr: | ||||||||||
85 |
- Citation: Lin KY, Chen GJ, Lee YL, Huang YC, Cheng A, Sun HY, Chang SY, Liu CE, Hung CC. Hepatitis A virus infection and hepatitis A vaccination in human immunodeficiency virus-positive patients: A review. World J Gastroenterol 2017; 23(20): 3589-3606
- URL: https://www.wjgnet.com/1007-9327/full/v23/i20/3589.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i20.3589