Recombinant adeno-associated virus carrying thymosin β4 suppresses experimental colitis in mice

Figure 3 Adeno-associated virus carrying thymosin β₄ improved 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice. A: Dynamic changes in DAI [the asterisk indicates ^aP < 0.05 vs PBS/2,4,6-trinitrobenzene sulfonic acid (TNBS) or adeno-associated virus (AAV)-LacZ/TNBS group]; B: TNBS treatment resulted in hyperemia, edema and ulceration, which were attenuated by Tβ₄; C: Macroscopic score of AAV-Tβ₄/TNBS group was significantly lower than those of the other two TNBS groups; D and E: Histological observation of colonic tissue (HE staining, magnification × 200) showed that AAV-Tβ₄ relieved TNBS-induced colonic mucosal lesions and reduced the histological score. Error bars indicate the SD. Scale bars = 50 μm. DAI: Disease activity index.