Diagnostic accuracy of transient elastography (FibroScan) in detection of esophageal varices in patients with cirrhosis: A meta-analysis

Table 3 Subgroup analysis: the diagnostic accuracy of FibroScan for the detection of large esophageal varices in cirrhotic patients

Subgroup	n	SEN (CI)	I2 (%)	SPE (CI)	I2 (%)	PLR (CI)	I2 (%)	NLR (CI)	I2 (%)	DOR (CI)	I2 (%)
LC etiology
One factor	5	0.79 (0.69-0.86)	24.7	0.75 (0.71-0.80)	84.3	2.82 (2.31-3.45)	78.9	0.30 (0.21-0.44)	0.0	9.05 (5.50-14.90)	49.3
Two factors	2	0.7 (0.62-0.78)	92.5	0.74 (0.69-0.79)	0.0	2.67 (2.00-3.57)	38.8	0.37 (0.13-1.02)	90.9	7.21 (2.07-25.16)	85.3
Multiple factors	6	0.80 (0.76-0.83)	40.9	0.76 (0.73-0.79)	92.1	3.02 (2.01-4.55)	90.7	0.27 (0.21-0.34)	21.2	12.46 (6.99-22.18)	68.5
Location
Europe	7	0.76 (0.72-0.80)	75.2	0.77 (0.75-0.80)	90.3	3.09 (2.03-4.70)	89.6	0.31 (0.21-0.48)	79.5	10.55 (5.04-22.07)	82.2
Asia	5	0.81 (0.75-0.86)	0.0	0.72 (0.69-0.76)	81.9	2.73 (2.37-3.15)	72.1	0.27 (0.21-0.36)	0.0	10.03 (7.01-14.35)	20.7
Africa	1	0.95	NA	0.67	NA		NA		NA		NA
Year
2006-2011	4	0.72 (0.64-0.78)	84.4	0.72 (0.68-0.76)	78.1	2.58 (2.06-3.24)	39.9	0.34 (0.18-0.62)	76.2	8.22 (3.94-17.15)	61.0
2012-2016	9	0.80 (0.76-0.83)	8.4	0.77 (0.74-0.79)	88.8	3.19 (2.28-4.46)	87.2	0.27 (0.23-0.32)	0.8	11.9 (7.10-20.01)	66.4
LS value (cutoff)
< 30 kPa	7	0.80 (0.76-0.84)	30.1	0.77 (0.74-0.79)	92.6	3.11 (2.01-4.81)	91.4	0.27 (0.20-0.35)	28.3	12.39 (6.60-23.27)	71.6
> 30 kPa	6	0.73 (0.67-0.79)	74.5	0.74 (0.70-0.77)	12.3	2.78 (2.40-3.21)	1.6	0.34 (0.22-0.53)	67.3	8.33 (4.94-14.05)	48.0

Publication year (2006-2011 year vs 2012-2016 year); Location (European vs Asia vs Africa) and Liver Stiffness Threshold (< 20 kPa vs > 20 kPa in the presence of EV; < 30 kPa vs > 30 kPa in the presence of Large EV) by using meta-regression model. SEN: Sensitivity; SPE: Specificity; NLR: Negative likelihood ratio; PLR: Positive likelihood ratio; DOR: Diagnostic odds ratio; NA: Not available; LC: Liver cirrhosis; LS: Liver stiffness.