Diagnostic accuracy of transient elastography (FibroScan) in detection of esophageal varices in patients with cirrhosis: A meta-analysis

Table 2 Subgroup analysis: the diagnostic accuracy of FibroScan for the detection of esophageal varices in cirrhotic patients

Subgroup	n	SEN (CI)	I2 (%)	SPE (CI)	I2 (%)	PLR (CI)	I2 (%)	NLR (CI)	I2 (%)	DOR (CI)	I2 (%)
LC etiology
One factor	5	0.76 (0.70-0.81)	56.5	0.68 (0.62-0.74)	55.6	2.26 (1.86-2.74)	37.3	0.37 (0.29-0.48)	25.3	6.17 (4.20-9.06)	30.4
Two factors	3	0.82 (0.77-0.85)	68.7	0.56 (0.48-0.63)	92.8	2.02 (0.96-4.27)	93.1	0.33 (0.19-0.58)	76.9	6.18 (1.86-20.55)	86.2
Multiple factors	5	0.89 (0.86-0.92)	62.0	0.61 (0.55-0.66)	86.2	2.48 (1.65-3.73)	81.0	0.16 (0.10-0.25)	56.8	16.74 (8.23-33.84)	57.9
Location
Europe	6	0.82 (0.79-0.86)	82.3	0.52 (0.46-0.58)	89.1	1.84 (1.33-2.55)	78.6	0.29 (0.18-0.49)	74.1	7.14 (3.06-16.66)	74.0
Asia	6	0.84 (0.81-0.87)	68.8	0.69 (0.64-0.73)	28.5	2.61 (2.25-3.03)	16.8	0.25 (0.21-0.30)	68.1	10.56 (7.93-14.07)	50.7
Africa	1	0.95	NA	0.67	NA		NA		NA		NA
Year
2006-2011	5	0.83 (0.80-0.87)	75.9	0.51 (0.44-0.57)	87.6	1.97 (1.39-2.78)	82.0	0.30 (0.19-0.46)	62.6	7.46 (3.43-16.24)	69.6
2012-2016	8	0.84 (0.81-0.87)	77.2	0.68 (0.64-0.73)	63.6	2.48 (2.0-3.07)	49.7	0.24 (0.16-0.36)	77.0	10.84 (5.94-19.77)	70.8
LS value (cutoff)
< 20 kPa	6	0.84 (0.80-0.87)	83.2	0.55 (0.50-0.61)	91.0	1.94 (1.37-2.74)	83.2	0.27 (0.16-0.47)	78.6	7.82 (3.36-18.24)	77.4
> 20 kPa	7	0.83 (0.80-0.86)	65.7	0.68 (0.63-0.72)	1.1	2.58 (2.22-3.00)	9.9	0.24 (0.20-0.29)	58.8	10.69 (7.97-14.34)	45.4

Publication year (2006-2011 year vs 2012-2016 year); Location (European vs Asia vs Africa) and Liver Stiffness Threshold (< 20 kPa vs > 20 kPa in the presence of EV; < 30 kPa vs > 30 kPa in the presence of Large EV) by using meta-regression model. SEN: Sensitivity; SPE: Specificity; NLR: Negative likelihood ratio; PLR: Positive likelihood ratio; DOR: Diagnostic odds ratio; NA: Not available; LC: Liver cirrhosis; LS: Liver stiffness.