Diagnostic accuracy of transient elastography (FibroScan) in detection of esophageal varices in patients with cirrhosis: A meta-analysis

Table 1 Descriptive characteristics of the eligible studies

Ref.	Location	Etiology (viral, %)	Simple	Mean age	Childs	Presence of EV	Large EV	Reference	Design	Presence of EV (Grade 0, 1)						Large EV (Grade 2, 3)
				(male,%)	score (%)	cutoff (kPa)	cutoff (kPa)	standard	method	TP	FP	FN	TN	SEN (%)	SPE (%)	TP	FP	FN	TN	SEN (%)	SPE (%)
Sporea et al[16], 2013	Romania	73.6	697	57 (57.20)	NR	NR	29.5	GIE	A							212	56	61	368	77.50	86.90
Sharma et al[17], 2013	India	29.9	174	49.3 (88.50)	A/B/C	27.3	NR	EGD	A	113	14	11	36	91.00	72.00
					32/57/11
Saad et al[18], 2013	Egypt	100	32	NR	A/B	29.7	38.2	GIE	B	19	4	1	8	95.00	67.00	10	5	0	17	100	77.30
					72/28
Nguyen-Khac et al[19], 2010	France	31.7	183	55.2 (64.50)	A/B/C	NR	48	EGD	A							30	38	11	104	73.20	73.20
					63/26/15
Li et al[20], 2012	China	100	158	47.4 (82.40)	NR	23.3	31.5	GIE	A	72	27	18	41	80.00	60.30	32	33	9	84	78.10	71.80
Li et al[21], 2014	China	84.2	260	49.4 (67.70)	NR	22.8	30.6	GIE	A	129	39	25	67	83.80	63.20	57	57	12	134	82.60	70.10
Kazemi et al[22], 2006	France	69.7	165	56 (67.30)	NR	13.9	19	UTE	A	70	52	4	39	95.00	91.00	43	47	4	71	91.00	60.00
Jung et al[23], 2008	Korea	46.4	112	53.3 (78.60)	NR	19.7	29.5	GIE	A	71	9	11	21	87.00	70.00	27	33	8	44	77.00	57.00
Hu et al[24], 2015	China	100	200	45.1 (71.00)	B/A + C	20.25	25.55	GIE	B	95	25	15	65	86.40	72.20	58	36	11	95	84.10	72.50
					84/16
Castéra et al[25], 2009	France	100	66	54.1 (60.00)	A/B + C	21.5	30.5	GIE	A	19	9	6	32	76.00	78.00	10	8	3	45	77.00	85.00
					70/30
Calvaruso et al[26], 2013	Italy	100	96	63.2 (69.80)	A	17	19	GIE	A	38	18	16	24	71.00	57.00	19	31	7	39	72.00	55.00
					100
Bintintan et al[27], 2015	Romania	45.0	60	57 (65.00)	A/B/C	15	28.8	EGD	A	45	0	2	13	95.00	100	28	5	4	23	87.20	82.76
					65/22/13
Stefanescu et al[28], 2011	Romania	NR	137	56 (56.20)	A/B/C,	28	NR	UTE	A	86	7	30	14	74.36	64.29
					65/28/7
Stefanescu et al[29], 2011	Romania	61.0	231	55.9 (58.40)	A/B/C,	19	38	UTE	A	132	50	25	24	84.00	32.39	38	40	30	123	55.56	75.32
					76/18/6
Wang et al[30], 2012	Taiwan	100	126	54.5 (73.80)	A,	12	21	EGD	A	32	18	16	60	67.00	77.00	10	15	3	98	77.00	87.00
					100

Design method: A: Cross-sectional; B: Case-control. EV: Esophageal varices; GIE: Gastrointestinal endoscopy; EGD: Esophagogastroduodenoscopy; UTE: Upper tract endoscopy; NR: No report; TP: True positive; FP: False positive; FN: False negative; TN: True negative; SEN: Sensitivity; SPE: Specificity.