Association between polymorphisms of the APOBEC3G gene and chronic hepatitis B viral infection and hepatitis B virus-related hepatocellular carcinoma

Table 5 Haplotype distributions between healthy controls and hepatocellular carcinoma patients, n (%)

Haplotype	Frequency		χ2	P value	OR (95%CI)
	Healthy controls	HCC
rs7291971-rs8177832
C-A	166 (29.0)	166 (29.4)	6.73	0.03	1
G-A	339 (59.3)	357 (63.3)			1.05 (0.81-1.37)
G-G	67 (11.7)	41 (7.3)			0.61 (0.39-0.95)
rs5757463-rs8177832
C-A	455 (80.4)	466 (81.8)	8.96	0.01	1
C-G	66 (11.7)	41 (7.2)			0.61 (0.40-0.91)
G-A	45 (8.0)	63 (11.1)			1.37 (0.91-2.05)
rs5757465-rs8177832
T-A	371 (66.0)	390 (69.9)	6.94	0.03	1
C-A	125 (22.2)	128 (22.9)			0.97 (0.73-1.30)
T-G	66 (11.7)	40 (7.2)			0.58 (0.38-0.88)
rs5757463-rs2011861
C-C	183 (33.2)	141 (25.4)	10.68	0.01	1
C-T	326 (59.1)	354 (63.7)			1.41 (1.08-1.83)
G-C	43 (7.8)	60 (10.8)			1.80 (1.15-2.82)
G-T	0 (0.0)	1 (0.2)			1.00 (0.99-1.02)
rs7291971-rs5757463-rs8177832
C-C-A	118 (21.1)	101 (18.0)	10.59	0.01	1
C-G-A	45 (8.0)	63 (11.3)			1.64 (1.03-2.61)
G-C-A	332 (59.3)	355 (63.4)			1.25 (0.92-1.70)
G-C-G	65 (11.6)	41 (7.3)			0.74 (0.46-1.18)
rs7291971-rs5757463-rs2011861
C-C-C	112 (20.4)	91 (16.6)	11.62	0.04	1
C-C-T	5 (0.9)	6 (1.1)			1.63 (0.42-6.42)
C-G-C	43 (7.8)	59 (10.8)			1.70 (1.05-2.76)
C-G-T	0 (0.0)	2 (0.4)			1.02 (0.99-1.05)
G-C-C	70 (12.8)	48(8.8)			0.85 (0.85-1.35)
G-C-T	319 (58.1)	342 (62.4)			1.33 (0.97-1.82)

HCC: Hepatocellular carcinoma.