Association between polymorphisms of the APOBEC3G gene and chronic hepatitis B viral infection and hepatitis B virus-related hepatocellular carcinoma

Table 3 Genotype and allele frequencies of single nucleotide polymorphisms in the APOBEC3G gene in each group

SNP	Healthy controls	Chronic HBV infection patients						Hepatitis B patients (n = 657) vs healthy controls (n = 299)
		Non-HCC, n = 370			HBV-related HCC, n = 287
	n = 299 (%)	n (%)	OR (95%CI)	P value1	n (%)	OR (95%CI)	P value2	OR (95%CI)	P value3
Rs7291971 genotype and allele
Detected number	n = 290	n = 366			n = 282			n = 648 vs n = 290
CC	28 (9.7)	36 (9.8)	1		26 (9.2)	1		1
CG	113 (39.0)	139 (38.0)	0.92 (0.53-1.61)	0.778	114 (40.4)	1.14 (0.63-2.09)	0.667	1.00 (0.61-1.66)	0.987
GG	149 (51.4)	191 (52.2)	0.98 (0.57-1.68)	0.935	142 (50.4)	1.14 (0.63-2.06)	0.664	1.04 (0.64-1.69)	0.891
CG + GG	262	330	0.95 (0.57-1.61)	0.867	256	1.14 (0.65-2.02)	0.651	1.02 (0.64-1.64)	0.930
C allele	169 (29.1)	211 (28.8)	1		166 (29.4)	1		1
G allele	411 (70.9)	521 (71.2)	1.02 (0.80-1.29)	0.901	398 (29.1)	0.99 (0.76-1.27)	0.913	1.00 (0.80-1.24)	0.983
Rs5757463 genotype and allele
Detected number	n = 285	n = 369			n = 285			n = 654 vs n = 285
CC	241 (84.6)	308 (83.5)	1		227 (79.6)	1		1
CG	43 (15.1)	56 (15.2)	1.02 (0.66-1.57)	0.944	53 (18.6)	1.34 (0.86-2.10)	0.202	1.16 (0.79-1.71)	0.456
GG	1 (0.4)	5 (1.4)	1.93 (0.37-10.14)	0.439	5 (1.8)	2.71 (0.51-14.31)	0.239	2.25 (0.49-10.39)	0.298
CG + GG	44	61	1.06 (0.69-1.62)	0.799	58	1.40 (0.91-2.17)	0.130	1.21 (0.83-1.77)	0.327
C allele	525 (92.1)	672 (91.1)	1		507 (88.9)	1		1
G allele	45 (7.9)	66 (8.9)	1.15 (0.77-1.70)	0.500	63 (11.1)	1.45 (0.97-2.17)	0.069	1.28 (0.90-1.82)	0.194
Rs5757465 genotype and allele
Detected number	n = 285	n = 365			n = 279			n = 644 vs n = 285
TT	170 (59.6)	221 (60.5)	1		169 (60.6)	1		1
TC	101 (35.4)	129 (35.3)	1.02 (0.73-1.42)	0.898	92 (33.0)	0.93 (0.65-1.34)	0.707	0.98 (0.73-1.32)	0.903
CC	14 (4.9)	15 (4.1)	0.82 (0.38-1.76)	0.610	18 (6.5)	1.43 (0.68-3.01)	0.349	1.05 (0.55-2.02	0.884
TC + CC	115	144	0.99 (0.72-1.37)	0.984	110	0.99 (0.70-1.39)	0.953	0.99 (0.74-1.32	0.945
T allele	441 (77.4)	571 (78.2)	1		430 (77.1)	1		1
C allele	129 (22.6)	159 (21.8)	0.95 (0.73-1.24)	0.714	128 (22.9)	1.02 (0.77-1.34)	0.902	0.98 (0.77-1.24)	0.868
Rs8177832 genotype and allele
Detected number	n = 291	n = 369			n = 287			n = 656 vs n = 291
AA	227 (78.0)	302 (81.8)	1		249 (86.8)	1		1
AG	60 (20.6)	65 (17.6)	0.80 (0.54-1.18)	0.253	35 (12.2)	0.53 (0.33-0.84)	0.007	0.67 (0.47-0.96)	0.029
GG	4 (1.4)	2 (0.5)	0.40 (0.72-2.26)	0.302	3 (1.0)	0.75 (0.16-3.43)	0.711	0.55 (0.15-2.07)	0.374
AG + GG	64	67	0.78 (0.53-1.14)	0.195	38	0.54 (0.35-0.85)	0.007	0.66 (0.47-0.94)	0.021
A allele	514 (88.3)	669 (90.7)	1		533 (92.9)	1		1
G allele	68 (11.7)	69 (9.3)	0.78 (0.55-1.11)	0.167	41 (7.1)	0.58 (0.39-0.87)	0.008	0.69 (0.50-0.95)	0.023
Rs2011861 genotype and allele
Detected number	n = 284	n = 364			n = 279			n = 643 vs n = 284
CC	53 (18.7)	55 (15.1)	1		33 (11.8)	1		1
CT	127 (44.7)	170 (46.7)	1.25 (0.80-1.95)	0.328	135 (48.4)	1.69 (1.02-2.80)	0.042	1.42 (0.95-2.13)	0.085
TT	104 (36.6)	139 (38.2)	1.27 (0.81-2.02)	0.301	111 (39.8)	1.82 (1.08-3.06)	0.024	1.48 (0.98-2.24)	0.063
CT + TT	231	309	1.26 (0.83-1.91)	0.277	246	1.75 (1.08-2.82)	0.022	1.45 (0.99-2.11)	0.053
C allele	233 (41.0)	280 (38.5)	1		201 (36.0)	1		1
T allele	335 (59.0)	448 (61.5)	1.11 (0.89-1.39)	0.350	357 (64.0)	1.24 (0.97-1.57)	0.085	1.16 (0.95-1.42)	0.140

P values represent the non-HCC¹, HCC², and chronic HBV³ infection patients compared to the healthy control groups adjusted for age, sex, smoking, and drinking by logistic regression analysis. The two-sided χ² test or Fisher’s exact test was used in alleles distribution comparison. HBV: Hepatitis B virus; HCC: Hepatocellular carcinoma.