Effects of heme oxygenase-1-modified bone marrow mesenchymal stem cells on microcirculation and energy metabolism following liver transplantation

Figure 11 Mitochondrial ultrastructure changes on the 7^th d after liver transplantation. A: Postoperative day (POD) 0; B: Normal saline (NS) group on POD7; C: Bone marrow-derived mesenchymal stem cells (BMMSCs) group on POD7; D: HO-1/BMMSCs group on POD7 (× 25000). The mitochondrial damage to hepatocytes was relatively severe in the NS group, with obvious swelling and vacuolized mitochondria and disturbed structures of mitochondrial cristae (some even disappeared). Mitochondria in the HO-1/BMMSCs and BMMSCs groups showed mild swelling, no vacuolization, and the integrated structures of the mitochondrial ridge were present.