Effects of heme oxygenase-1-modified bone marrow mesenchymal stem cells on microcirculation and energy metabolism following liver transplantation

Figure 5 Endothelin-1 expression in the liver after liver transplantation. A: Immunohistochemistry (IHC) of endothelin-1 (ET-1); B: IHC integrated optical density (IOD) of ET-1; C: ET-1 protein levels. ET-1 protein levels: postoperative day (POD) 1: HO-1/BMMSCs group vs BMMSCs group vs NS group: 0.04 ± 0.02 vs 0.07 ± 0.01 vs 0.27 ± 0.02 (P < 0.05). POD5: HO-1/BMMSCs group vs BMMSCs group vs NS group: 0.29 ± 0.01 vs 0.35 ± 0.01 vs 0.45 ± 0.01 (P < 0.01). POD7: HO-1/BMMSCs group vs BMMSCs group vs NS group: 0.28 ± 0.03 vs 0.34 ± 0.01 vs 0.42 ± 0.02 (P < 0.05). POD14: HO-1/BMMSCs group vs BMMSCs group vs NS group: 0.27 ± 0.04 vs 0.51 ± 0.01 vs 0.71 ± 0.01 (P < 0.01). ^aP < 0.05 vs NS group, ^cP < 0.05 vs HO-1/BMMSCs group.