Renin angiotensin system in liver diseases: Friend or foe?

Figure 2 Potential mechanisms of hepatorenal syndrome. The hemodynamic changes associated with advanced stages of cirrhosis may lead to reductions in renal blood flow and in the glomerular filtration rate (GFR) as a compensatory mechanism to the low systemic vascular resistance and arterial hypotension. The kidney hypoperfusion is the hallmark of hepatorenal syndrome (HRS) and occurs as a consequence of the activation of systemic vasoconstrictor factors, including the classical axis of the renin angiotensin system (RAS), sympathetic nervous system and antidiuretic hormone (ADH). The increase in kidney vasoconstriction negatively influences its function, ultimately leading to HRS. Legend: Ang II: Angiotensin II; SNS: Sympathetic nervous system; SVR: Systemic vascular resistance.