Nissen fundoplication vs proton pump inhibitors for laryngopharyngeal reflux based on pH-monitoring and symptom-scale

Table 4 Comparison of outcome between laparoscopic Nissen fundoplication and proton pump inhibitor administration by 2-year follow-up

Characteristic/parameter	LNF (n = 25)	PPI (n = 28)	P value
BMI (kg/m2)
Pre-treatment	24.9 ± 3.8	25.0 ± 3.1	0.285
Post-treatment	22.2 ± 3.12	25.1 ± 2.9	0.0011
RSI score (value)
Pre-treatment	15.3 ± 3.5	14.2 ± 4.0	0.759
Post-treatment	9.7 ± 4.12	12.8 ± 3.12	0.0041
RSI score (≥ 13), n (%)
Pre-treatment	19 (76.0)	24 (85.7)	0.284
Post-treatment	7 (28.0)2	19 (67.9)2	0.0031
PPI independence, n (%)	11(44.0)	2 (7.14)	0.0001
Satisfaction, n (%)	62.49 ± 28.68	44.36 ± 32.77	0.0041

¹Represent statistical significant P values between LNF and PPI group;

²Represent statistical significant P values between pre-treatment and post-treatment for 2-year follow-up (P < 0.05). Values are given as mean ± SD or n (%). LNF: Laparoscopic Nissen fundoplication; PPI: Proton pump inhibitor.