Nissen fundoplication vs proton pump inhibitors for laryngopharyngeal reflux based on pH-monitoring and symptom-scale

Table 3 Comparison of the laryngopharyngeal and gastroesophageal reflux disease typical symptom score between laparoscopic Nissen fundoplication and proton pump inhibitor groups before treatment and at 6-mo and 2-year follow-up

Characteristic/symptom score (No. of LNF/PPI)	Baseline (n = 70)			6-mo follow-up (n = 61)			2-yr follow-up (n = 53)
	LNF	PPI	P value	LNF	PPI	P value	LNF	PPI	P value
Regurgitation2 (17/20)	6.47 ± 0.62	6.24 ± 0.56	0.385	1.41 ± 1.69	2.53 ± 1.15	0.0221	1.12 ± 1.47	2.53 ± 1.26	0.0051
Heartburn2 (19/20)	6.33 ± 0.68	6.30 ± 0.59	0.100	1.33 ± 1.06	2.60 ± 1.69	0.0081	0.94 ± 1.10	3.05 ± 2.20	0.0011
Cough (15/16)	7.71 ± 0.82	7.67 ± 0.46	0.804	2.34 ± 2.37	4.40 ± 2.10	0.0221	2.28 ± 2.12	5.00 ± 2.28	0.0121
Mucus (11/9)	7.09 ± 0.83	7.22 ± 0.44	0.824	2.82 ± 2.24	4.77 ± 1.85	0.0551	3.27 ± 2.18	5.29 ± 1.78	0.0201
Globus (23/14)	6.10 ± 0.66	7.01 ± 0.88	0.268	2.95 ± 2.75	5.43 ± 2.50	0.0131	2.77 ± 2.87	5.28 ± 2.86	0.0171
Hoarseness (10/7)	7.30 ± 2.78	7.33 ± 2.55	0.954	3.80 ± 2.69	5.00 ± 2.65	0.409	3.50 ± 2.76	4.33 ± 2.53	0.546
Throat pain (11/4)	7.20 ± 1.03	7.50 ± 0.58	0.552	3.70 ± 2.98	5.50 ± 2.65	0.100	3.20 ± 3.46	4.25 ± 2.06	0.166
Throat clearing (6/7)	7.67 ± 0.52	7.14 ± 0.52	0.063	3.33 ± 2.06	6.00 ± 1.53	0.0341	2.83 ± 2.40	6.28 ± 1.51	0.0201

¹Represent statistical significant P values (P < 0.05);

²Represents gastroesophageal reflux disease typical symptoms. Values are given as mean ± SD. LNF: Laparoscopic Nissen fundoplication; PPI: Proton pump inhibitor.