Relationship between use of selective serotonin reuptake inhibitors and irritable bowel syndrome: A population-based cohort study

Table 4 Hazard ratio of irritable bowel syndrome associated with duration of selective serotonin reuptake inhibitor exposure over one year

	aHR1	(95%CI)	P value
SSRI non-users	1.00	(reference)
SSRI exposure < 90 d	3.27	(2.61-4.08)	< 0.001
SSRI exposure 90-180 d	1.38	(1.03-1.85)	0.029
SSRI exposure 181-270 d	1.49	(1.05-2.13)	0.027
SSRI exposure ≥ 270 d	1.52	(1.07-2.15)	0.020

¹aHR, adjusted by age, sex, urbanization, family income, area of residence, occupation, anti-psychotics and the comorbidities listed in Table 1. SSRI: Selective serotonin reuptake inhibitor.