Tumor-associated autoantibodies are useful biomarkers in immunodiagnosis of α-fetoprotein-negative hepatocellular carcinoma

doi:10.3748/wjg.v23.i19.3496

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 21, 2017; 23(19): 3496-3504
Published online May 21, 2017. doi: 10.3748/wjg.v23.i19.3496

Table 2 Frequency of autoantibodies against NPM1, 14-3-3zeta and MDM2 in human sera by enzyme-linked immunosorbent assay n (%)

Type of sera	No. tested	Frequency of autoantibody
Type of sera	No. tested	NPM1	14-3-3zeta	MDM2	Combination of 3 proteins
AFP(-)HCC	56	12 (21.4)^b	11 (19.6)^b	11 (19.6)^a^b	17 (30.4)^b
AFP(+)HCC	86	9 (10.5)	8 (9.3)	14 (16.3)	18 (20.9)
CLD	168	9 (5.4)	11 (6.5)	15 (8.9)	18 (10.7)
NHC	59	1 (1.7)	0 (0)	1 (1.7)	1 (1.7)

Cut-off value, mean ± 3 SD of NHCs.

^aP < 0.05 and

^bP < 0.01 (value relative to CLD and NHC). AFP: Alpha fetoprotein; CLD: Chronic liver disease; HCC: Hepatocellular carcinoma; NHC: Normal human control; NPM1: Nucleophosmin 1; MDM2: Mouse double minute 2 homolog.

Citation: Wang T, Liu M, Zheng SJ, Bian DD, Zhang JY, Yao J, Zheng QF, Shi AM, Li WH, Li L, Chen Y, Wang JH, Duan ZP, Dong L. Tumor-associated autoantibodies are useful biomarkers in immunodiagnosis of α-fetoprotein-negative hepatocellular carcinoma. World J Gastroenterol 2017; 23(19): 3496-3504
URL: https://www.wjgnet.com/1007-9327/full/v23/i19/3496.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i19.3496