Insulin-like growth factor-1, IGF binding protein-3, and the risk of esophageal cancer in a nested case-control study

Table 4 Odds ratios and 95%CI for esophageal cancer according to molar difference of insulin-like growth factor-1 and insulin-like growth factor-binding protein-3 (subgroup)

	Tertile			P value
	1 (referent)	2	3
Molar difference	< 87.77	87.77-108.14	> 108.14
Male
No. of case/control	15 / 28	7/22	3/25
OR (95%CI)	1	0.339 (0.085-1.349)	0.044 (0.004-0.527)	0.011
OR adjusted (95%CI)	1	0.186 (0.034-1.015)	0.022 (0.001-0.319)	0.004
≤ 65 years old
No. of case/control	11/14	7/21	3/27
OR (95%CI)	1	0.260 (0.052-1.300)	0.031 (0.025-0.400)	0.007
OR adjusted (95%CI)	1	0.226 (0.042-1.224)	0.028 (0.002-0.389)	0.007

Adjusted: Adjusted for cigarette smoking, BMI, and alcohol intake.