Insulin-like growth factor-1, IGF binding protein-3, and the risk of esophageal cancer in a nested case-control study

Table 2 Odds ratios and 95%CI for esophageal cancer with reference to serum concentrations of insulin-like growth factor-1 and insulin-like growth factor-binding protein-3

	Tertile			P value
	1 (referent)	2	3
IGF1
ng/mL (range)	< 120	120-150	> 150
No. of case/control	17/27	8/33	6/26
OR (95%CI)	1	0.300 (0.098-0.913)	0.263 (0.068-1.011)	0.036
OR adjusted 1 (95%CI)	1	0.292 (0.087-0.982)	0.265 (0.064-1.092)	0.052
OR adjusted 2 (95%CI)	1	0.281 (0.077-1.023)	0.387 (0.071-2.112)	0.247
OR adjusted 3 (95%CI)	1	0.298 (0.080-1.109)	0.417 (0.074-2.348)	0.249
IGFBP3
ng/mL (range)	< 2.88	2.88-3.55	> 3.55
No. of case/control	18/30	9/27	4/29
OR (95%CI)	1	0.518 (0.171-1.564)	0.133 (0.023-0.786)	0.024
OR adjusted 1 (95%CI)	1	0.527 (0.155-1.792)	0.137 (0.021-0.911)	0.042
OR adjusted 4 (95%CI)	1	0.914 (0.241-3.468)	0.182 (0.025-1.329)	0.140
OR adjusted 5 (95%CI)	1	0.853 (0.210-3.468)	0.192 (0.023-1.585)	0.196

Adjusted 1: Adjusted for cigarette smoking, BMI, and alcohol intake; Adjusted 2: Adjusted for IGFBP3; Adjusted 3: Adjusted for cigarette smoking, BMI, alcohol intake, and IGFBP3; Adjusted 4: Adjusted for IGF1; Adjusted 5: Adjusted for cigarette smoking, BMI, alcohol intake, and IGF1.