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©The Author(s) 2017.
World J Gastroenterol. May 21, 2017; 23(19): 3480-3487
Published online May 21, 2017. doi: 10.3748/wjg.v23.i19.3480
Published online May 21, 2017. doi: 10.3748/wjg.v23.i19.3480
Table 3 Genotype and allele frequencies in control and gastric cancer patients and odds ratio of gastric cancer by genotypes n (%)
Genotype | Controls (n = 508) | Gastric cancer patients (n = 474) | OR | 95%CI | P value |
IL12B (rs1368439) | |||||
TT | 366 (72.05) | 338 (71.31) | 1.00 | ||
TG | 137 (26.97) | 127 (26.79) | 0.87 | 0.63-1.18 | 0.39 |
GG | 5 (0.98) | 9 (1.90) | 1.27 | 0.39-4.14 | 0.68 |
GG vs TG + TT | 1.33 | 0.41-4.30 | 0.63 | ||
GG + TG vs TT | 0.88 | 0.65-1.20 | 0.42 | ||
Allele T | 869 (85.53) | 803 (84.70) | 1.00 | 0.83-1.45 | 0.63 |
Allele G | 147 (14.47) | 145 (15.30) | 1.10 | ||
INSR (1051690) | |||||
CC | 334 (65.75) | 272 (57.51) | 1.00 | ||
CT | 153 (30.12) | 182 (38.48) | 1.45 | 1.08-1.95 | 0.01 |
TT | 21 (4.13) | 19 (4.02) | 1.30 | 0.66-2.60 | 0.44 |
TT vs CT + CC | 1.15 | 0.58-2.30 | 0.70 | ||
TT + CT vs CC | 1.44 | 1.08-1.90 | 0.01 | ||
Allele C | 821 (80.81) | 726 (76.74) | 1.00 | ||
Allele T | 195 (19.19) | 220 (23.26) | 1.32 | 1.04-1.67 | 0.02 |
CCND1 (rs7177) | |||||
AA | 160 (31.56) | 159 (33.62) | 1.00 | ||
AC | 245 (48.32) | 220 (46.51) | 0.92 | 0.68-1.26 | 0.63 |
CC | 102 (20.12) | 94 (19.87) | 1.07 | 0.73-1.58 | 0.70 |
CC vs AC + AA | 1.12 | 0.80-1.60 | 0.50 | ||
CC + AC vs AA | 0.97 | 0.72-1.30 | 0.83 | ||
Allele A | 565 (55.72) | 538 (56.87) | 1.00 | ||
Allele C | 449 (44.28) | 408 (43.13) | 1.02 | 0.84-1.24 | 0.81 |
IL10 (rs3024498) | |||||
TT | 252 (50.30) | 259 (54.87) | 1.00 | ||
TC | 217 (43.31) | 185 (39.19) | 0.92 | 0.69-1.22 | 0.57 |
CC | 32 (6.39) | 28 (5.93) | 1.05 | 0.58-1.87 | 0.88 |
CC vs TC + TT | 1.08 | 0.29-1.61 | 0.78 | ||
CC + TC vs TT | 0.94 | 0.71-1.23 | 0.64 | ||
Allele T | 721 (71.96) | 703 (74.47) | 1.00 | ||
Allele C | 281 (28.04) | 241 (25.53) | 1.03 | 0.83-1.30 | 0.78 |
- Citation: Petkevicius V, Salteniene V, Juzenas S, Wex T, Link A, Leja M, Steponaitiene R, Skieceviciene J, Kupcinskas L, Jonaitis L, Kiudelis G, Malfertheiner P, Kupcinskas J. Polymorphisms of microRNA target genes IL12B, INSR, CCND1 and IL10 in gastric cancer. World J Gastroenterol 2017; 23(19): 3480-3487
- URL: https://www.wjgnet.com/1007-9327/full/v23/i19/3480.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i19.3480