Thiopurine use associated with reduced B and natural killer cells in inflammatory bowel disease

Figure 3 Thiopurine-associated lymphopenia is due to decreased NK cells. CD3- lymphocytes (A) and CD56+, CD19- subsets thereof (B-F) per milliliter of blood were calculated from flow cytometry performed on PBMC from healthy controls (open grey circles) vs IBD patients on (black triangles) vs not on thiopurines (grey squares). Total CD56+ NK (B) and CD16+ (C), NKp46+ (D), CD56^low (E), and CD56^high fractions thereof are shown. P values reflect two-tailed Mann-Whitney non-parametric comparisons.