Thiopurine use associated with reduced B and natural killer cells in inflammatory bowel disease

Figure 1 Thiopurine use is associated with lymphopenia, but not T cell depletion. A: Leukocyte subsets from clinical complete blood cell differentials are shown for healthy controls and inflammatory bowel disease (IBD) patients on or not on a thiopurine medication at the time of sampling. Total (B) and regulatory (C) T cell (Treg) subsets per mL of blood were calculated from flow cytometry performed on PBMC from healthy controls (open grey circles) vs IBD patients on (black triangles) vs not on thiopurines (grey squares). Treg data is also shown as a percent of total CD4+ T cells. P values reflect two-tailed Mann-Whitney non-parametric comparisons. NS: P > 0.05.