Low-FODMAP diet reduces irritable bowel symptoms in patients with inflammatory bowel disease

doi:10.3748/wjg.v23.i18.3356

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Controlled Trial

World J Gastroenterol. May 14, 2017; 23(18): 3356-3366
Published online May 14, 2017. doi: 10.3748/wjg.v23.i18.3356

Table 3 Results of irritable bowel syndrome-symptom severity system response in subgroups of inflammatory bowel disease patients on low FODMAP

	Number	Week 0	Week 6	P value
Ulcerative colitis (UC)
UC	55 (71)	220 (190-300)	124 (40-198)	< 0.01
LFD	26 (47)	225 (187-260)	120 (36-170)	< 0.01
ND	29 (53)	220 (185-315)	141 (52-263)	< 0.01
0.37¹
Crohn’s disease (CD)
CD	23 (29)	245 (170-320)	170 (56-294)	< 0.01
LFD	11 (48)	210 (160-320)	58 (18-173)	0.02
ND	12 (52)	250 (172-382)	220 (57-357)	0.54
0.02¹
UC vs CD, P = 0.24¹
IBD-Remission by SCCAI/HBI
Remission	65 (83)	230 (175-305)	140 (39-212)	< 0.01
LFD	31 (48)	220 (170-250)	105 (26-167)	< 0.01
ND	34 (52)	242 (177-322)	175 (77-298)	< 0.01
< 0.01¹
IBD Mild-to-Moderate Activity by SCCAI/HBI
Activity	13 (17)	210 (200-350)	140 (103-252)	0.53
LFD	6 (46)	210 (194-391)	169 (105-332)	0.17
ND	7 (54)	260 (200-330)	140 (96-211)	0.06
0.53¹
Remission vs Activity, P < 0.01¹
FC-remission (≤ 100 μg/g UC, ≤ 200 μg/g CD), n = 53
Remission	53 (73)	220 (179-305)	113 (34-225)	< 0.01
LFD	25 (47)	220 (174-305)	60 (29-169)	< 0.01
ND	28 (53)	230 (180-307)	174 (66-298)	< 0.01
0.06¹
FC-activity (> 100 μg/g UC; > 200 μg/g CD), n = 20
Activity	20 (27)	250 (204-330)	160 (110-211)	< 0.01
LFD	11 (55)	210 (200-250)	157 (95-198)	0.04
ND	9 (45)	320 (230-360)	170 (103-291)	0.03
0.50¹
FC-Remission vs FC-Activity, P = 0.29¹
CRP-remission (< 10 mg/L), n = 75
Remission	75 (96)	230 (180-320)	140 (50-211)	< 0.01
LFD	35 (47)	210 (187-260)	114 (30-169)	< 0.01
ND	40 (53)	248 (180-320)	176 (78-288)	< 0.01
< 0.01¹
CD, prior surgery (bowel/ileo-coecal resections), n = 13/23 (57%)
LFD	11	225 (178-302)	10 (32-223)	< 0.01
ND	2	-	-

¹P: Mann-Whitney U test comparison of change in outcomes between treatment groups at 6-wk. All data are presented as median (IQR: Interquartile range), n (%) (- only 2 cases). P: Wilcoxon signed rank test, comparison of paired samples within each treatment group. IBS: Irritable bowel syndrome; SSS: Severity score system; IBD: Inflammatory bowel disease; LFD: Low FODMAP diet; ND: Normal Diet.

Citation: Pedersen N, Ankersen DV, Felding M, Wachmann H, Végh Z, Molzen L, Burisch J, Andersen JR, Munkholm P. Low-FODMAP diet reduces irritable bowel symptoms in patients with inflammatory bowel disease. World J Gastroenterol 2017; 23(18): 3356-3366
URL: https://www.wjgnet.com/1007-9327/full/v23/i18/3356.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i18.3356