Low-grade slightly elevated and polypoid colorectal adenomas display differential β-catenin-TCF/LEF activity, c-Myc, and cyclin D1 expression

Figure 5 Markers of downstream apoptosis signaling. Bcl-2 (A) and Bcl-xL (B) protein expression were significantly upregulated in slightly elevated lesions relative to polypoid lesions. Caspase-9 (C) and caspase-3 (D) activity were both significantly downregulated in slightly elevated lesions relative to polypoid lesions. ^aP < 0.05, slightly elevated vs polypoid.