Low-grade slightly elevated and polypoid colorectal adenomas display differential β-catenin-TCF/LEF activity, c-Myc, and cyclin D1 expression

Figure 1 Comparative mutational analysis of commonly mutated genes. A: Total coverage of the five commonly-mutated genes under investigation based on the Catalogue of Somatic Mutations in Cancer (COSMIC) database. The solid bars represent the overall mutational percentages according to the COSMIC database, while the hashed bars represent the subset of mutational percentages covered under the current study. The total numbers of samples analyzed by the COSMIC database are stated on top of each bar. B: Among the five genes analyzed, APC and KRAS were the most frequently mutated genes in both lesions. Slightly elevated lesions showed a significantly lower APC mutational frequency as well as a significantly higher KRAS mutational frequency relative to polypoid lesions. ^aP < 0.05, slightly elevated vs polypoid.