BRAF inhibitor treatment of melanoma causing colonic polyps: An alternative hypothesis

Figure 1 Treatment with BRAF inhibitors may lead to colonic adenomas mimicking serrated adenomas with characteristics of cellular senescence, CpG island methylation phenotype, but with BRAF mutations instead substituted by altered RAF homo and hetero dimers. Later selective gene silencing can cause loss of senescence and progression to colorectal cancer. CIMP: CpG island methylation phenotype.