Impact of gastroesophageal reflux control through tailored proton pump inhibition therapy or fundoplication in patients with Barrett’s esophagus

Table 2 Histology (hematoxylin and eosin staining) of the distal squamous epithelium, proximal Barrett’s esophagus and distal Barrett’s esophagus at baseline and after successful acid reflux suppression with increasing doses of proton pump inhibitor in non-operated patients (group 1) and anti-reflux operated Barrett’s esophagus patients (group 2), with and without normal acid reflux

Variable	Group 1, baseline(n = 23)	Group 1, no reflux(n = 23)	P value	Group 2, reflux(n = 14)	Group 2, no reflux(n = 16)	P value
Squamous epithelium
Dilated intercellular space (%)	87.0	73.9	< 0.05	78.6	68.8	0.50
Basal cell thickness (% score 0/1/2)	4.3/82.7/13.0	21.7/69.6/8.7	0.22	50.0/50.0/0	12.5/87.5/0	< 0.05
Papillary length (% score 0/1/2)	0/34.8/65.2	8.7/52.2/39.1	< 0.05	7.1/42.9/50.0	18.8/43.7/37.5	0.53
Epithelial neutrophils and eosinophils (% score 0/1/2)	39.2/30.4/30.4	47.8/26.1/26.1	0.86	35.7/50.0/14.3	62.5/25/12.5	0.27
Epithelial mononuclear cells (% score 0/1/2)	60.9/39.1/0	87.0/13.0/0	0.09	57.1/42.9/0	56.3/43.7/0	0.47
Proximal BE
Epithelial neutrophils and eosinophils (% score 0/1/2)	43.5/30.4/26.1	47.8/30.4/21.7	0.06	42.9/21.4/35.7	81.3/6.2/12.5	< 0.05
Epithelial mononuclear cells (% score 0/1/2)	91.3/8.7/0	95.7/4.3/0	0.26	92.9/7.1/0	93.7/6.3/0	0.24
Distal BE
Epithelial neutrophils and eosinophils (% score 0/1/2)	78.3/8.7/13.0	82.6/13/4.4	0.74	85.7/0/14.3	43.8/50/6.2	< 0.05
Epithelial mononuclear cells (% score 0/1/2)	73.9/13.0/13.0	56.5/39.1/4.4	0.10	92.9/7.1/0	100/0/0	0.09

BE: Barrett’s esophagus.