Effect of a counseling-supported treatment with the Mediterranean diet and physical activity on the severity of the non-alcoholic fatty liver disease

doi:10.3748/wjg.v23.i17.3150

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. May 7, 2017; 23(17): 3150-3162
Published online May 7, 2017. doi: 10.3748/wjg.v23.i17.3150

Table 3 Anthropometric, clinical and metabolic parameters at baseline, mid-intervention (3M) and end-intervention (6M) and results of the statistical analysis

Parameter	mean ± SD, BL	mean ± SD, 3M	mean ± SD, 6M	P value
Parameter	mean ± SD, BL	mean ± SD, 3M	mean ± SD, 6M	BL vs 3M	3M vs 6M	BL vs 6M
BMI (kg/m²)	29.3 ± 6.11	28.0 ± 6.21	27.5 ± 6.21	< 0.01^a	< 0.01^a	< 0.01^a
Waist circumference (cm)	101.25 ± 13.63	97.50 ± 14.07	96.24 ± 13.64	< 0.01^a	< 0.01^a	< 0.01^a
Hip-to-waist ratio	0.95 ± 0.08	0.94 ± 0.07	0.93 ± 0.08	< 0.01^a	< 0.01^a	< 0.01^a
AST (U/L)	36.16 ± 21.11	28.73 ± 11.28	24.84 ± 10.70	< 0.01^a	< 0.01^a	< 0.01^a
ALT (U/L)	65.66 ± 31.92	48.37 ± 33.44	37.33 ± 19.53	< 0.01^a	< 0.01^a	< 0.01^a
GGT (U/L)	60.19 ± 61.43	41.35 ± 36.49	39.73 ± 35.36	< 0.01^a	0.545	< 0.01^a
FA (U/L)	81.48 ± 37.19	79.54 ± 32.04	80.04 ± 35.02	0.489	0.787	0.574
Total cholesterol (mg/dL)	215.24 ± 40.78	205.04 ± 41.75	207.18 ± 38.48	0.044^a	0.598	0.097
LDL cholesterol (mg/dL)	137.70 ± 32.87	131.25 ± 35.88	130.16 ± 32.65	0.071	0.941	0.050^a
HDL cholesterol (mg/dL)	49.72 ± 10.59	50.17 ± 11.64	53.09 ± 11.86	0.550	< 0.01^a	< 0.01^a
TG (mg/dL)	133.39 ± 67.77	123.65 ± 71.31	118.24 ± 65.14	0.112	0.358	0.017^a
Serum glucose (mg/dL)	98.33 ± 15.87	94.52 ± 13.07	95.76 ± 13.46	< 0.01^a	0.133	< 0.01^a
Chol Tot/HDL	4.50 ± 1.27	4.23 ± 1.07	3.95 ± 1.15	0.013^a	0.010^a	< 0.01^a
LDL/HDL	2.89 ± 0.95	2.67 ± 0.93	2.56 ± 0.84	0.028^a	0.015^a	< 0.01^a
TG/HDL	2.87 ± 1.76	2.66 ± 1.89	2.39 ± 1.66	0.152	0.037^a	< 0.01^a
AIP	0.03 ± 0.25	-0.01 ± 0.23	-0.06 ± 0.25	0.097	0.089	< 0.01^a
HOMA- IR (mU/L)	3.25 ± 1.96	2.96 ± 1.73	2.94 ± 1.67	< 0.01^a	0.841	< 0.01^a
QUICKI	0.33 ± 0.04	0.34 ± 0.04	0.34 ± 0.03	< 0.01^a	0.330	< 0.017^a
PLR	115.37 ± 46.60	109.89 ± 51.77	113.65 ± 43.77	0.195	0.281	0.816
NLR	1.98 ± 1.12	1.88 ± 1.10	1.79 ± 0.89	0.287	0.509	0.185
FLI	61.55 ± 26.76	50.54 ± 29.37	48.83 ± 31.01	< 0.01^a	0.286	< 0.01^a
Kotronen index (%)	6.05 ± 5.02	4.10 ± 2.22	3.92 ± 2.40	< 0.01^a	0.277	< 0.01^a
VAI	1.85 ± 1.17	1.55 ± 0.71	1.32 ± 0.65	0.011	0.010	< 0.01^a
NAFLD Liver Fat Score	0.12 ± 1.63	-0.02 ± 1.42	-0.70 ± 1.20	0.418	< 0.01^a	< 0.01^a
LAP (male)	48.41 ± 28.14	37.01 ± 19.95	33.18 ± 17.49	< 0.01^a	0.166	< 0.01^a
LAP (female)	84.15 ± 63.06	78.92 ± 70.51	74.13 ± 58.89	0.290	0.452	< 0.01^a
BARD	1.09 ± 1.26	1.46 ± 1.17	1.37 ± 1.04	0.011^a	0.486	0.091
NAFLD	-2.29 ± 0.93	-2.13 ± 1.01	-2.28 ± 1.00	0.015^a	0.032^a	0.986

Values are expressed as mean ± SD.

^aP ≤ 0.05, significant difference. BL: Baseline; NAFLD: Non-alcoholic fatty liver disease; TG: Triglycerides; HDL: High-density lipoprotein; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; GGT: Gamma-glutamyl transferase.

Citation: Gelli C, Tarocchi M, Abenavoli L, Di Renzo L, Galli A, De Lorenzo A. Effect of a counseling-supported treatment with the Mediterranean diet and physical activity on the severity of the non-alcoholic fatty liver disease. World J Gastroenterol 2017; 23(17): 3150-3162
URL: https://www.wjgnet.com/1007-9327/full/v23/i17/3150.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i17.3150