Prognostic value of the neutrophil-to-lymphocyte ratio for hepatocellular carcinoma patients with portal/hepatic vein tumor thrombosis

Table 5 Univariate and multivariate analyses of factors affecting disease-free survival

Variables	Univariate analysis for DFS			Multivariate analysis for DFS
	HR	95%CI	P value	HR	95%CI	P value
NLR > 2.9	1.720	1.017-2.907	0.043	1.553	0.850-2.837	0.153
Age ≤ 50 yr	1.424	0.842-2.409	0.188
Female	1.593	0.384-6.610	0.522
HBsAg (+)	1.314	0.407-4.249	0.648
HBV-DNA > 1 × 103	1.426	0.772-2.634	0.257
AFP ≥ 400 ng/mL	2.099	1.196-3.684	0.010	1.732	0.954-3.146	0.071
ALT ≤ 40 U/L	1.272	0.771-2.098	0.346
Hgb > 130 g/L	2.629	1.266-5.460	0.010	2.051	0.940-4.476	0.071
PLT ≤ 100 × 109/L	1.147	0.413-3.186	0.793
Child B	1.254	0.631-2.492	0.518
ICGR15 ≤ 10%	2.470	1.052-5.796	0.038	2.134	0.870-5.236	0.098
Multiple tumors	1.189	0.709-1.992	0.512
Maximum diameter of tumor > 5 cm	1.865	0.944-3.686	0.073
Bilobular disease	1.778	0.753-4.199	0.189
Adjacent organ not invaded	1.119	0.659-1.899	0.677
Major hepatectomy	1.253	0.635-2.474	0.516
Pringle maneuver	1.922	0.933-3.960	0.076
Operation time ≤ 180 min	1.067	0.638-1.785	0.805
Intraoperative blood loss > 1000 mL	1.854	1.012-3.396	0.046	1.258	0.649-2.437	0.497
Intraoperative blood transfusion	1.655	0.972-2.817	0.064
Surgical margin ≤ 1 cm	1.492	0.827-2.690	0.183
Histologic grade I-II	1.083	0.648-1.808	0.761
Postoperative complication	1.173	0.608-2.264	0.634
Postoperative hospital stay > 10 d	1.041	0.616-1.759	0.882

NLR: Neutrophil-to-lymphocyte ratio; DFS: Disease-free survival; HBV: Hepatitis B virus; AFP: Alpha fetoprotein; ALT: Alanine aminotransferase; PLT: Platelet.