Prognostic value of the neutrophil-to-lymphocyte ratio for hepatocellular carcinoma patients with portal/hepatic vein tumor thrombosis

Table 4 Univariate and multivariate analyses of factors affecting overall survival

Variables	Univariate analysis for OS			Multivariate analysis for OS
	HR	95%CI	P value	HR	95%CI	P value
NLR > 2.9	1.969	1.190-3.259	0.008	1.866	1.048-3.322	0.034
Age ≤ 50 yr	1.532	0.913-2.569	0.106
Female	2.035	0.625-6.623	0.238
HBsAg (+)	1.055	0.327-3.402	0.929
HBV-DNA > 1 × 103	1.258	0.709-2.234	0.432
AFP ≥ 400 ng/mL	2.026	1.163-3.527	0.013	1.863	1.024-3.392	0.042
ALT ≤ 40 U/L	1.122	0.684-1.839	0.649
Hgb > 130 g/L	1.964	0.987-3.909	0.054
PLT > 100 × 109/L	1.168	0.467-2.916	0.740
Child A	1.090	0.564-2.106	0.798
ICGR15 ≤ 10%	1.642	0.746-3.610	0.218
Multiple tumors	1.676	1.022-2.748	0.041	1.084	0.627-1.876	0.772
Maximum diameter of tumor > 5 cm	1.869	0.973-3.593	0.061
Bilobular disease	2.764	1.153-6.628	0.023	3.292	1.215-8.918	0.019
Adjacent organ invaded	1.268	0.756-2.127	0.369
Major hepatectomy	1.145	0.597-2.195	0.683
Pringle maneuver	1.937	0.950-3.952	0.069
Operation time > 180 min	1.352	0.819-2.233	0.238
Intraoperative blood loss > 1000 mL	1.721	0.957-3.096	0.070
Intraoperative blood transfusion	1.485	0.901-2.448	0.121
Surgical margin ≤ 1 cm	1.868	1.024-3.408	0.042	1.195	0.596-2.394	0.616
Histologic grade III-IV	1.220	0.736-2.020	0.440
Postoperative complication	1.467	0.807-2.667	0.209
Postoperative hospital stay ≤ 10 d	1.078	0.646-1.798	0.774

NLR: Neutrophil-to-lymphocyte ratio; OS: Overall survival; HBV: Hepatitis B virus; AFP: Alpha fetoprotein; ALT: Alanine aminotransferase; PLT: Platelet.