Prognostic value of the neutrophil-to-lymphocyte ratio for hepatocellular carcinoma patients with portal/hepatic vein tumor thrombosis

Table 2 Clinicopathological characteristics of the 81 hepatocellular carcinoma patients with portal/hepatic vein tumor thrombosis, n (%)

	NLR ≤ 2.9 (n = 51)	NLR > 2.9 (n = 30)	P value
Age in years	48.49 ± 1.52	48.47 ± 2.28	0.993
Gender			0.292
Male	48 (94.1)	30 (100.0)
Female	3 (5.9)	0 (0.0)
HBsAg status			0.281
Negative	3 (5.9)	0 (0.0)
Positive	45 (88.2)	30 (100.0)
Unknown	3 (5.9)	0 (0.0)
Preoperative HBV DNA			0.025
< 1 × 103	19 (37.3)	4 (13.3)
≥ 1 × 103	23 (45.1)	19 (63.3)
Unknown	9 (17.6)	7 (23.3)
Preoperative AFP level			0.038
< 400 ng/mL	19 (37.3)	5 (16.7)
≥ 400 ng/mL	30 (58.8)	25 (83.3)
Unknown	2 (3.9)	0 (0.0)
Preoperative ALT level (U/L)	41 (10-713)	42.5 (21-146.5)	0.697
Preoperative Hgb level (g/L)	147.79 ± 2.43	148.52 ± 4.37	0.884
Preoperative PLT level (109/L)	185.84 ± 12.73	201.97 ± 13.97	0.417
Preoperative Child-Pugh score			0.017
Child A (5)	21 (41.2)	7 (23.3)
Child A (6)	22 (43.1)	14 (46.7)
Child B (7)	4 (7.8)	5 (16.7)
Child B (8)	1 (2.0)	2 (6.7)
Child B (9)	0 (0.0)	1 (3.3)
Unknown	3 (5.9)	1 (3.3)
Preoperative ICGR15 (%)	6.42 ± 0.79	5.37 ± 0.94	0.404
Number of tumors			0.474
Solitary	28 (54.9)	14 (46.7)
Multiple	23 (45.1)	16 (53.3)
Maximum diameter of tumor (cm)	8.93 ± 0.58	11.88 ± 0.80	0.003
Uni/bilobular disease			0.414
Unilobular disease	48 (94.1)	26 (86.7)
Bilobular disease	3 (5.9)	4 (13.3)
Adjacent organ invasion			0.722
Negative	32 (62.7)	20 (66.7)
Positive	19 (37.3)	10 (33.3)
Operative procedure			0.215
Minor	45 (88.2)	23 (76.7)
Major	6 (11.8)	7 (23.3)
Total occlusion time of the hepatic inflow (min)	17.89 ± 1.58	18.18 ± 2.53	0.918
Total operative time (min)	168.43 ± 7.19	205.00 ± 13.77	0.011
Blood loss (mL)	579.41 ± 61.82	891.67 ± 171.61	0.095
Blood transfusion (mL)			0.061
No	33 (64.7)	13 (43.3)
Yes	18 (35.3)	17 (56.7)
Surgical margin			0.002
≤ 1 cm	33 (64.7)	25 (83.3)
> 1 cm	18 (35.3)	1 (3.3)
Unknown	0 (0.0)	4 (13.3)
Histological grade of tumor cells			0.958
I-II	19 (37.3)	11 (36.7)
III-IV	32 (62.7)	19 (63.3)
Postoperative complication			0.792
Negative	42 (82.4)	24 (80.0)
Positive	9 (17.6)	6 (20.0)
Postoperative hospital stay (d)	11 (8-28)	11.5 (8-83)	0.468

NLR: Neutrophil-to-lymphocyte ratio.