BRAF inhibitor treatment of melanoma causing colonic polyps: An alternative hypothesis

doi:10.3748/wjg.v23.i17.3022

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May 7, 2017 (publication date) through Jan 11, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 7, 2017; 23(17): 3022-3029
Published online May 7, 2017. doi: 10.3748/wjg.v23.i17.3022

Table 2 Pathways enriched for BRAF mutant associated promoter methylation

BRAF mutations specific promoter	Associated genes
PI3 kinase pathway	FOXB1; FOXB2, FOXD3, CCND1, GSK3A
Insulin/IGF pathway	FOXB1; FOXB2, FOXD3; GSK3A
Hedgehog signaling pathway	SMO; GSK3A; CREBBP
Wnt signaling	NKD2; GNG4; CCND1; GSK3A; CREBBP
Transcription-regulation by bZIP transcription factor	CREBBP, MTERF; TAF7

Citation: Kelleher FC, Callaghan G, Gallagher C, O’Sullivan H. BRAF inhibitor treatment of melanoma causing colonic polyps: An alternative hypothesis. World J Gastroenterol 2017; 23(17): 3022-3029
URL: https://www.wjgnet.com/1007-9327/full/v23/i17/3022.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i17.3022