Effects of Hwangryunhaedok-tang on gastrointestinal motility function in mice

Figure 2 Increasing effect of extract of Hwangryunhaedok-tang on normal gastric emptying and on loperamide- or cisplatin- induced delayed gastric emptying. A 5-HT4 receptor agonist (mosapride, 5 mg/kg) or a dopamine receptor antagonist (domperidone, 5 mg/kg) was administered in distilled water. A: After a 24 h fast, animals (n = 6/group) were orally dosed with HHTE at the indicated dosages; B: Loperamide-induced gastric emptying (GE) delay was prevented by Lizhong Tang extract; C: Lizhong Tang pretreatment prevented cisplatin-induced GE delay. GE percentages were calculated as described in Materials and Methods. Bars represent mean ± SE. ^aP < 0.05, ^eP < 0.001. Significantly different from normal controls. Mosa.: Mosapride; Dom.: Domperidone; p.o.: per os, oral administration; i.p.: Intraperitoneally.