Changes in human hepatic metabolism in steatosis and cirrhosis

Figure 3 Liver disease is associated with significant changes in energy and protein metabolism and ketone body production. Fraction intensity boxplots for indicated metabolites in normal liver (nl), ARLD (arld) and NASH (nash) liver samples. For each metabolite shown, an unpaired t-test (Welch's t-test) was calculated with a 5% cut-off to test the null hypothesis that the relative peak intensities for pairs of the different classes have the same mean, variances not assumed to be equal. The solid line indicates the median fractional intensity, and the box shows the interquartile range. Outlier samples are indicated by red crosses and statistical analyses are indicated in Supplemental Table 1. NASH: Nonalcoholic steatohepatitis; ARLD: Alcohol-related liver damage.